Fibromyalgia: an inflammation of the brain demonstrated for the first time

The generalized inflammation in the brains of fibromyalgia patients has just been identified. A real progress compared to this little known and little recognized disease.
For the first time, researchers have discovered widespread inflammation of the brain in patients with fibromyalgia *, a little known disease. What to develop new therapies His report was published in the journal Brain, Behavior and Immunity. “The discovery of objective neurochemical changes in the brains of patients with fibromyalgia should help reduce the persistent stigma faced by many patients, and they are often told that their symptoms are imaginary and that they have nothing.” -he. Marco Loggia, Research Director.

The diagnosis of fibromyalgia remains difficult to establish
Chronic pain is the main symptom of fibromyalgia. Other symptoms (fatigue, sleep disturbances, memory loss, etc.) differ from one patient to another and change over time. Despite the identification of these clinical manifestations, the diagnosis of fibromyalgia remains difficult to establish. To date, no laboratory or radiological examination has been able to confirm this.

We analyzed 20 fibromyalgia patients and 14 control volunteers in a first team. At the same time, another group of researchers had formed a cohort of 11 patients and an equal number of control participants. Scientists compared their data to draw common conclusions.

Activation of glial cells in various regions of the brain.
Finally, activation of glial cells in several brain regions of fibromyalgia patients was significantly higher than in control participants. In the nervous system, glial cells are the cells that form the environment of neurons. “The activation of glial cells that we observed in our studies releases inflammatory mediators supposed to sensitize the pain pathways and contribute to symptoms such as fatigue,” concludes Marco Loggia. *

Fibromyalgia affects between 2 and 5% of the French population, according to the association Fibromyalgie France, and about 4 million adults in the United States. Although the World Health Organization (WHO) recognized fibromyalgia as a disease in 1992, this is not yet the case in France, but the earliest writings on this syndrome date back to the 18th century.


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